Carissa carandas

KARAMARDA (Root)
Karamarda consists of dried root of Carissa carandas Linn. (Fam. Apocynaceae); a dichotomously branched large shrub or small tree with strong simple or forked thorns in pairs, found throughout the country.
 
SYNONYMS
Sansk : Karamla, Karamardaka
Assam : —
Beng : Karamacha
Eng : —
Guj : Karamada
Hindi : Karaonda, Karaondi
Kan : Karayige
Kash : —
Mal : Modakam
Mar : Karabanda
Ori : —
Punj : —
Tam : Kalakkai
Tel : Vaka, Karavande
Urdu : —
 
DESCRIPTION –
 
a) Macroscopic:
Root considerably long, often irregularly bent, woody, cylindrical; rusty or yellowish-brown; 1-1.5 cm thick; surface smooth; fracture, hard; odour and taste, not distinct.
 
b) Microscopic:
Mature root shows a stratified cork, lignified and tangentially elongated cells, consisting of alternating bands of smaller and larger cells; a few inner layers filled with red contents; secondary cortex very narrow, composed of 1 or 2 layers of thinwalled cells; secondary phloem composed of usual elements having a number of cavities, present in a row just below the secondary cortex; a number of stone cells present in large compact patches in different rows, in outer and inner phloem regions interrupting phloem rays; phloem rays uni-to biseriate; prismatic crystals of calcium oxalate occur in a number of cells throughout phloem region; cambium not distinct; secondary xylem very wide consisting of xylem vessels, fibres, tracheids and xylem parenchyma, all elements being lignified, xylem rays uni to biseriate, consisting of radially elongated cells; simple, round to oval, starch grains measuring 5.5-11 µ in dia., present throughout.
Powder – Yellowish-brown; shows patches of stratified cork, xylem fibres, stone cells, prismatic crystals of calcium oxalate and simple, round to oval, starch grains, measuring 5.5 – 11 µ in dia.
 
CONSTITUENTS – Glycosides -Cardiac Glycosides.
 
PROPERTIES AND ACTION –
Rasa : Katu, Tikta
Guna : Laghu, Ruksha
Virya : sita
Vipaka : Katu
Karma : Mhutrala, Vamaka
 
IMPORTANT FORMULATIONS – Marma Gutika
 
THERAPEUTIC USES – Mhutra Roga, Visphota, Vidradhi, Vrana.
 
DOSE – 1-3 g. of the drug in powder form.